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doi: 10.1056/NEJMoa2212948 273 Van RooyI.Cakir-TasciogluS.HenninkW

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Recently, studies have shown that ROS, as cellular signaling molecules, could trigger autophagosome formation and autophagic degradation (Filomeni et al., 2015

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Together, these results indicate that decreased GSH/GSSG redox/antioxidant capacity and increased oxidative stress in the autism brain may have functional consequence in terms of a chronic inflammatory response, increased mitochondrial superoxide production, and oxidative protein and DNA damage